Most cars use a key to power and start the engine. A key that won't turn in the key cylinder can be extremely frustrating especially if you have appointments to make or you are stranded somewhere. A car must be in the park position in order to turn a key. A steering wheel may also lock disabling you from turning the key. Worn keys won't turn the ignition cylinder and must be replaced.
Place the shift lever completely in park. The key will not turn in a car that is in between gears.
Turn the steering wheel from left to right. A steering wheel can lock up occasionally causing the key cylinder to lock and your key unable to turn.
Turn the key counterclockwise to the "Off" position and then clockwise to the desired position.
Have a new key made by the car dealer.