Lexus released the RX-series of SUVs in the 1999 model year, with the launch of the RX300. As the engine size increased in the RX, the name changed as well. In 2004, a 3.3-liter engine replaced the 3.0-liter, and Lexus changed the name to the RX330. In 2007, the 3.5-liter V-6 replaced the 3.3-liter, and the name changed to RX350. The 2007 RX350 came standard with a direct tire-pressure-monitoring system, which had a pressure sensor mounted in each tire. When the pressure drops in one tire a light illuminates on the dashboard to alert the driver. Anytime you perform a tire rotation or replace the TPMS computer, you must reset the TPMS system.
Set all four tires to 30 psi, as recommended by the manufacturer, using compressed air with a tire inflation attachment.
Engage the RX350's parking brake. Insert the key in the ignition and turn it to the "On" position, but don't start the vehicle.
Press and hold the tire-pressure-monitoring system reset button --- a small, black button under the dashboard, to the right of the steering column --- until the tire pressure warning light blinks three times, each blink lasting 1 second.
Leave the ignition in the "On" position while the system initializes, which typically takes several minutes. Turn the ignition "Off" when the TPMS warning light extinguishes.