Chevy equipped the 2000 S10 pickup with a 2.2-liter, inline four-cylinder engine bolted to an NV1500 manual transmission as standard equipment. Chevy offered the 4L60-E four-speed automatic as an option. The optional 4.3-liter V-6 engine came with either the 4L60-E automatic or an NV3500 manual transmission. Chevy's fluid recommendation is different for each transmission.
In the owner's manual that came with the 2000 S10, Chevy recommended Dexron III fluid for the 4L60E automatic transmission. However, service bulletin No. 04-07-30-037D released in November of 2007, changed that recommendation to Dexron VI.
Chevy recommends Synchromesh Transmission Fluid -- GM Part No. 12345349
or equivalent -- for manual transmissions bolted up to the 4.3-liter V-6 engine. They recommend Friction Modified Synchromesh Transmission Fluid -- GM Part No. 12377916 or equivalent -- for manual transmissions bolted up to the 2.2-liter engine.
